AVALIAÇÃO DAS QUIMIOCINAS CCL2/MCP-1, CCL5/RANTES, CXCL8/IL- 8, CXCL9/ MIP, CXCL10/IP-10 EM PACIENTES INTUBADOS COM ENFERMIDADES RESPIRATÓRIAS

Abstract

Objective of word: To compare the levels of CXCL10/IP-10, CCL2/MCP-1, CXCL9/MIG, CCL5/RANTES, and CXCL8/IL-8 in the oral mucosa and endotracheal tube of patients who progressed to extubation or death. Materials and Methods: This observational study included 45 patients submitted to Invasive Mechanical Ventilation (IMV) in an intensive care unit. Samples were collected from the oral mucosa and endotracheal tube and analyzed by Cytometric Bead Array (CBA). Patients were classified according to clinical outcome: extubation (n=13) or death (n=32). Results: In extubated patients, CXCL10/IP-10 levels were significantly lower in the oral mucosa compared to CCL2/MCP-1, CCL5/RANTES, and CXCL8/IL-8, and significantly lower in the endotracheal tube compared to CXCL8/IL-8. Patients who progressed to death exhibited significantly higher CXCL8/IL-8 levels in the oral mucosa compared to CXCL10/IP-10, CCL2/MCP-1, CXCL9/MIG, and CCL5/RANTES, and significantly higher CCL5/RANTES levels compared to CXCL10/IP-10; in the endotracheal tube, CXCL10/IP-10 was significantly lower than the other chemokines. Comparatively, patients who died presented significantly higher levels of CXCL9/MIG, CCL5/RANTES, and CXCL8/IL-8 in the oral mucosa compared to extubated patients. Conclusion: Mechanically ventilated patients exhibited distinct chemokine profiles in the oral mucosa according to clinical outcome. Significantly higher levels of CXCL9/MIG, CCL5/RANTES, and CXCL8/IL-8 in the oral mucosa are associated with death, suggesting that oral swab analysis may represent a promising tool for early identification of prognostic biomarkers in patients with pneumonia. Future studies with larger samples and longitudinal designs will be important to validate these findings and to further explore the potential of these molecules as prognostic tools in intensive care settings.